Though the hybridoma technology has been widely applied in the production of monoclonal antibodies, it has existed some disadvantages including low yield and genetic instability.Therefore, an alternative approach should be taken into account.Recently, recombinant monoclonal antibody technology has emerged as the best choice to cure hybridoma relate
Interaction between sphingosine and cholesteryl sulfate in epidermal lipids.
Free sphingosine, a material with multiple and potent biological activities, is known to occur in high concentration in mammalian epidermis.In the present study, thin-layer chromatography showed that in lipid extracts of human and pig stratum corneum, sphingosine Bean Bag forms a relatively stable compound with endogenous cholesteryl sulfate.NMR sp
Integrative analysis of bulk and single-cell RNA-seq reveals the molecular characterization of the immune microenvironment and oxidative stress signature in melanoma
Background: The immune microenvironment and oxidative stress of melanoma show significant heterogeneity, which affects tumor growth, invasion and treatment response.Single-cell and bulk RNA-seq data were used to explore the heterogeneity of the immune microenvironment Jackets/Outerwear and oxidative stress of melanoma.Methods: The R package Seurat
Homeobox Genes in Cancers: From Carcinogenesis to Recent Therapeutic Intervention
The homeobox (HOX) genes encoding an evolutionarily highly conserved family of homeodomain-containing transcriptional factors are essential for embryogenesis and tumorigenesis.HOX genes are MASSAGE OIL involved in cell identity determination during early embryonic development and postnatal processes.The deregulation of HOX genes is closely associat